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Efek Hepatoprotektif Ekstrak Etanol Daun Keji Beling (Strobilanthes crispus) pada Tikus Jantan Galur Wistar yang Diinduksi Parasetamol Berdasarkan Kadar SGOT dan SGPT

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Keji beling leaves have the potential as a hepatoprotector. This study aims to
determine the hepatoprotective activity of ethanol extract of keji beling leaves
(EEDKB) on SGOT and SGPT levels in male wistar rats induced by paracetamol.
The study used experimental research with a randomized matched pre-test and
post-test control group design. EEDKB was made using the maceration method
with 70% ethanol. A total of 24 rats were divided into 6 groups, namely normal
control, negative control (CMC Na 0.5% 25mL/KgBW), positive control
(Curcumin 200mg/KgBW), EEDKB 150mg/KgBW, EEDKB 300mg/KgBW,
EEDKB 600mg/KgBW. The test suspension was given orally for 12 days.
Paracetamol was given on the 12th day after 2 hours of treatment (except for normal
controls). Blood serum samples were taken on day 0 and day 12 to measure SGOT
and SGPT levels. The percentage of SGOT and SGPT levels were determined
statistically with a 95% confidence level.
The average percentage of SGOT levels decreased by EEDKB 150, 300, and
600mg/KgBB were 7.68; 20.85; 29.75, respectively. While the average percentage
of SGPT levels decreased by EEDKB 150, 300, and 600mg/KgBB were 13.81;
20.28; 31.98, respectively. All percentages of SGOT and SGPT levels decreased
higher than the negative control. So it can be concluded that EEDKB has a
hepatoprotective effect.
Keywords: Ethanol extract of keji beling leaves, Hepatoprotective, Paracetamol,
SGOT, SGPT

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

600

Penerbit

: ., 2024

Deskripsi Fisik

83 hlm

Bahasa

Indonesia

ISBN/ISSN

175010169

Klasifikasi

600

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Prodi Ilmu Farmasi
Fakultas Farmasi

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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